Read
Yohimbe Dangers Yohimbine
interacts with the dopaminergic system to reverse sexual satiation:
further evidence for a role of
sexual motivation in sexual exhaustion
by
Rodriguez-Manzo G
Departamento de Farmacologia y Toxicologia,
CINVESTAV, Mexico, D.F., Mexico.
Eur J Pharmacol 1999 May 7; 372(1):1-8
ABSTRACT
The
possible interaction of yohimbine with the dopaminergic system in the
mediation of sexual behaviour expression in sexually exhausted
male rats
was investigated. The behavioural effects of the simultaneous injection
of yohimbine (500 microg/kg) plus apomorphine (50
microg/kg) and those
of the combined treatment of haloperidol (125 microg), a nonspecific
dopamine receptor antagonist, with an effective
dose of yohimbine (2000
microg/kg) on sexually satiated rats were evaluated. Data show that yohimbine and apomorphine, per se, dose-
dependently reverse sexual
exhaustion by increasing the percentage of sexually satiated rats
copulating and resuming copulation after
ejaculation. Injection of
haloperidol simultaneous to an effective dose of yohimbine, blocked the
ability of the latter to reverse sexual
satiation. The combined
treatment with subthreshold doses of apomorphine and yohimbine
synergised to reverse the sexual inhibition
characteristic of sexual
exhaustion. Data suggest that the dopaminergic system might be the final
pathway for the yohimbine-induced sexual
behaviour expression in
satiated rats. The possible role of sexual motivation in the sexual
exhaustion phenomenon is discussed.
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