ScienceDaily (Sep. 16, 2008) —
Scientists at Sunnybrook Research Institute (SRI) are developing and
commercializing a promising novel therapy for the treatment of prostate
cancer that may offer patients a faster and more precise treatment than
existing clinical alternatives, with fewer side effects.
The new treatment—magnetic resonance imaging (MRI)-guided
transurethral ultrasound—uses heat from focused ultrasound to treat
cancer in the prostate gland precisely while sparing the delicate
noncancerous tissues around the prostate essential for healthy urinary,
bowel and sexual function.
Sunnybrook researchers Dr. Michael Bronskill and Dr. Rajiv Chopra
have licensed their innovation and formed Profound Medical Inc., which
will develop the technology for clinical use.
Unlike surgical removal of the prostate, the treatment is minimally
invasive and could be performed without a lengthy hospital stay. In
preclinical studies, treatment takes less than 30 minutes. The therapy,
on which clinicians at Sunnybrook will conduct preliminary testing in
preparation for a clinical trial, could help limit the number of men
living with the common, debilitating and often permanent side effects of
surgery and radiation treatments currently used. More of these invasive
therapies are being performed now because improved awareness among
younger men has converged with better clinical detection tools.
Profound's clinical development is targeted at treatment that reduces
the high level of incontinence and impotence associated with
current,
invasive treatments. The therapy involves two different and naturally
incompatible technologies, ultrasound and MRI, which Bronskill and
Chopra spent 10 years making compatible. "You have to make an ultrasound
heating applicator work inside a magnetic resonance imager, without the
two technologies interfering with each other," says Bronskill, who is a
professor at the University of Toronto. "The prostate cancer site is a
natural for this technology because it's surrounded by structures you
want to spare."
Dr. Laurence Klotz, chief of urology at Sunnybrook Health Sciences
Centre, and a professor at the University of Toronto, says that a
noninvasive therapy for early, localized prostate cancer could improve
the quality of life of hundreds of thousands of men. "The key to
effective noninvasive treatment is accurate imaging of the target organ
and of the effects of the treatment on tissue. In that respect,
MR-guided ultrasound has many potential advantages over transrectal
ultrasound-guided focused ultrasound, now approved for use in Canada,"
says Klotz.
The scientists' creation of this clinically viable product was done
in a setting committed to commercialization. "At SRI, we are dedicated
not only to developing new and better therapies and technologies, but
also to getting those discoveries to our patients," says Dr. Michael
Julius, vice-president of research at Sunnybrook. Profound Medical Inc.
is the third imaging-technology company to be spun out of research at
SRI in recent years. The other two are VisualSonics Inc. and Sentinelle
Medical Inc.
The Terry Fox Foundation, Ontario Research and Development Challenge
Fund and Canadian Institutes of Health Research funded early-stage
development of the scientists' work. Early in 2008 the Ontario Institute
for Cancer Research, which is funded by the government of Ontario,
invested $500,000, which spurred venture capital interest and led to the
formation of Profound.
Prostate cancer is the most common cancer among Canadian men. The
Canadian Cancer Society estimates 24,700 men will be
diagnosed with the
disease in 2008 and 4,300 will die of it.
Sunnybrook Health Sciences Centre (2008, September 16). New
Treatment For Prostate Cancer Pioneered. ScienceDaily.
Retrieved September 18, 2008, from http://www.sciencedaily.com
/releases/2008/09/080915121325.htm
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