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Hong Kong experts warn against anti-impotence "remedies"

By Tan Ee Lyn Thursday, Oct. 11, 2007; 2:27 PM
 

HONG KONG (Reuters) - Researchers have warned about "herbal remedies" for erectile dysfunction sold over-the-counter in Hong Kong after most of them were found to contain untested variants of well-known anti-impotence drugs.

These variants, or "analogues", are copies of controlled drugs but they are slightly modified in their chemical structure to escape patent and other drug-related laws.

Cranked out illegally, these chemicals are not tested for their efficacy or safety and can have unpredictable, adverse effects. They are added undeclared into "health products", which do not come under stringent tests in most countries.

Writing in the latest issue of the Hong Kong Medical Journal, the scientists said they studied 26 anti-impotence products sold in convenience stores and pharmacies.

Although their packaging declared that they contained only "herbal ingredients", variants of sildenafil and vardenafil were found in 14 of them. Sildenafil was found in one product.

Sildenafil and vardenafil are generic names for their better known trade labels Viagra and Levitra, respectively, and they are prescribed drugs in Hong Kong.

"The positive rate of concealed drug analogues in male erectile dysfunction health products is alarmingly high. Such analogues are difficult to detect by ordinary laboratory methods and might be used in an attempt to evade regulatory inspection," wrote the researchers at the Hospital Authority Toxicology Reference Laboratory in the journal's October issue.

"Without going through the stringent drug testing process, the adverse effects of these chemicals remain largely unknown and unpredictable," they warned, as they called for urgent and more effective surveillance and control.

"The medical profession and the public should be alerted to this under-recognized threat."

This malpractice came to light when a previously healthy 28-year-old man got admitted to hospital for an unsteady gait and frequent falls -- signs of ataxia.

Doctors then learnt that he had taken an anti-impotence "health product" for over a week before showing those symptoms.

Classified as phosphodiesterase-5 inhibitors, sildenafil and vardenafil are known to have side-effects like nausea, headache, facial flushing and visual disturbances. Serious cardiovascular effects have also been reported.

But ataxia has never been linked to this class of drugs.

"Unlike the parent pharmaceutical, no formal studies have been performed to assure the safety and efficacy of these analogues," the researchers wrote.

"Evidently, the adverse effects of drug analogues are highly unpredictable and the consumption of such products is dangerous

 

Contamination of herbal products with prescription medications is an extraordinarily deadly scam. In the present case, drugs for erectile dysfunction (ED) apparently were deliberately mixed with various almost useless herbs. This deliberate adulteration has two obvious potential effects. First, the prescription drug can increase the effect and mislead the user into thinking that the herbs did work. Secondly, there's a risk of side effects (including death) if the patient has been taking other drugs that interact with prescription ED drugs and/or has medical conditions that preclude the use of ED drugs.

Anyone considering ordering "Herbal Viagra" or similar products should be aware of this deceptive practice.

As of 13May2004, there are about 172,000 webpages at Google found by searching for webpages containing the phrase "herbal viagra." ----Posted on diabetesmonitor.com


From Reuters: (1)

"Herbal" Viagra and other so-called natural alternatives for treating impotence advertised on the Internet and in men's magazines are often contaminated with real drugs and could kill those who take them, researchers said on Monday…

Fleshner and colleagues bought seven "herbal" erectile dysfunction products to find out what was in them. Two contained significant levels of prescription phosphodiesterase inhibitors -- sildenafil, sold by Pfizer under the brand name Viagra and tadalafil, Eli Lilly and Co's Cialis.

"We think the implications of this are quite dramatic," Fleshner told a news conference. "Since these compounds are not natural, deliberate contamination of these products must be considered," added Fleshner, whose team presented the findings to a meeting of the American Urological Association in San Francisco.

The erectile dysfunction drugs affect blood flow and can be deadly when taken with certain heart drugs containing nitrates.

 

 


 

From the abstract of the report (2)

We set out to determine if marketed herbal preparations for the treatment of ED contained PDE5 inhibitors [phosphodiesterase (PDE5) inhibitors include Viagra, Cialis, and Levitra]. Methods: We purchased seven brands of marketed herbal products for the treatment of ED. Purchases were limited to oral tablets or capsules that claimed to improve erection quality if consumed prior to sexual activity…

Results: Significant contamination with sildenafil and tadalafil was detected in two out of 7 of the herbal preparations examined…

Conclusions: Since PDE5 inhibitors are not natural, deliberate contamination of these products must be considered. Consumers and regulatory agencies must be aware of these findings as these agents have known fatal interactions with prevalently consumed drugs (e.g. nitrates). These findings also seriously challenge the concept of safety of CAM agents.

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Recommended LuvHerbs™ Dosage:

Tribulus to increase female sex libido: Take one Tribulus tablet twice per day, everyday at breakfast and at
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To be ready for sex on a less frequent basis,
take two each of Tribulus, Tongkat ali, & Arginine two to three
     hours in advance of sexual activity. Take with one full glass of water.


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