Grape Extracts May Be Effective
Against Harmful Gut Bacteria
ScienceDaily (Mar. 8, 2009) — In
a new study researchers from Clemson University found various grape
extracts and their compounds to be effective at inhibiting Helicobacter
pylori, one of the leading causes of gastritis in humans.
H. pylori is the bacterial agent most commonly associated with peptic
ulcers, gastritis, mucosa-associated lymphoid tissue lymphoma, and
gastric cancer. Antibiotic therapy has proven effective at providing
initial relief, however resistance can develop over time and relapse can
occur. Previous studies have examined other natural plant extracts with
anti-H. pylori activity such as garlic, broccoli, cranberries and green
tea, however, grapes have yet to be evaluated despite being well known
for their high levels of antioxidants and polyphenols.
The antibacterial effects of extracts from red, white, black and
muscadine grapes as well as the pure compounds resveratrol, ellagic
acid, and myricetin were tested for anti-H. pylori activity using agar
dilution, laser scanning microscopy and cell proliferation. Following 24
hour treatment, results showed that muscadine grape skin extract had the
highest anti-H. pylori effect, followed by muscadine grape synergy and
seed extract. Additionally, two of the three compounds, resveratrol and
ellagic acid, also inhibited H. pylori.
"In this study, grape extracts and their compounds were effective at
inhibiting H. pylori in vitro, with highest efficacy by muscadine grape
skin extract," say the researchers.
Journal reference:
1.
Brown et al. Antibacterial Effects of Grape Extracts on
Helicobacter pylori. Applied and Environmental Microbiology,
2008; 75 (3): 848 DOI:
10.1128/AEM.01595-08
Adapted from materials provided by
American Society for Microbiology.
American Society for Microbiology (2009, March 8). Grape Extracts May
Be Effective Against Harmful Gut Bacteria. ScienceDaily.
Retrieved March 12, 2009, from http://www.sciencedaily.com
/releases/2009/03/090304132621.htm
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