Ginseng, nitric oxide, and sex
This study
reports that “Recent studies in laboratory animals have shown that both
Asian and American forms of ginseng enhance libido and copulatory
performance.”
Ginseng, sex behavior, and
nitric oxide.
L.L. Murphy, T.J. Lee,
Department of Physiology, Southern Illinois University, School of Medicine,
Carbondale, Illinois 62901, USA.
lmurphy@siumed.edu,
Ann N Y Acad Sci. 2002 May;962:372-7.
In Asia, ginseng is commonly
included in herbals used for the treatment of sexual dysfunction. Recent
studies in laboratory animals have shown that both Asian and American forms
of ginseng enhance libido and copulatory performance. These effects of
ginseng may not be due to changes in hormone secretion, but to direct
effects of ginseng, or its ginsenoside components, on the central nervous
system and gonadal tissues. Indeed, there is good evidence that ginsenosides
can facilitate penile erection by directly inducing the vasodilatation and
relaxation of penile corpus cavernosum. Moreover, the effects of ginseng on
the corpus cavernosum appear to be mediated by the release and/or
modification of release of nitric oxide from endothelial cells and
perivascular nerves. Treatment with American ginseng also affects the
central nervous system and has been shown to significantly alter the
activity of hypothalamic catecholamines involved in the facilitation of
copulatory behavior and hormone secretion. Recent findings that ginseng
treatment decreased prolactin secretion also suggested a direct nitric
oxide-mediated effect of ginseng at the level of the anterior pituitary.
Thus, animal studies lend growing support for the use of ginseng in the
treatment of sexual dysfunction and provide increasing evidence for a role
of nitric oxide in the mechanism of ginsenoside action.
PMID: 12076988 [PubMed - indexed for MEDLINE
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