Chinese Herbal Erection
University of
California San Francisco School of Medicine Medical Study Discovers that
Chinese Herbal Medicine Helps Erection
Department of Urology, University of California San
Francisco, School of Medicine, San Francisco, California, USA, "Effect of a
Chinese herbal medicine mixture on a rat model of hypercholesterolemic
erectile dysfunction," conducted by medical researchers M. E. Bakircioglu,
K.. Hsu, A. El-Sakka, K.D. Sievert, C.S. Lin, T.F. Lue, Journal of
Urology, 2000 Nov;164(5):1798-801
.
PURPOSE: We examine the effect of a Chinese herbal
medicine mixture on erectile function in a rat model of hypercholesterolemic
erectile dysfunction. MATERIALS AND METHODS: In this study 32, 3-month-old
Sprague-Dawley rats were used. The 8 control animals were fed a normal diet
and the remaining 24 were fed 1% cholesterol diet for 4 months. After 2
months herbal medicine was added to the drinking water of the treatment
group of 16 rats but not the cholesterol only group of 8. Of the 16 rats 8
received 25 mg./kg. per day (group 1) and 8 received 50 mg./kg. per day
(group 2) of Chinese herbal medicine mixture. Serum cholesterol levels were
measured at 2 and 4 months. At 4 months erectile function was evaluated with
cavernous nerve electrostimulation in all animals. Penile tissues were
collected for electron microscopy, and to perform Western blot for
endothelial nitric oxide synthase, neuronal nitric oxide synthase, basic
fibroblast growth factor (bFGF) and caveolin-1. RESULTS: Serum cholesterol
levels were significantly higher in animals fed the 1% cholesterol diet
compared to controls at 2 and 4 months. Nevertheless, there was no
significant difference among group 1 (145 +/- 30 mg./dl.), group 2 (157 +/-
20) and the cholesterol only group (143 +/- 15). Systemic arterial pressure
was not significantly different between the animals that were fed the 1%
cholesterol diet and the controls. During
electrostimulation of the cavernous nerve peak sustained intracavernous
pressure was significantly lower in the cholesterol only group (50 +/- 23
cm. H2O) compared to the control group. Conversely erectile function was not
impaired in the herbal medicine treated rats. Electron microscopy
showed many caveolae with fingerlike processes in the cavernous smooth
muscle and endothelial cell membranes in control and treated rats but not in
the cholesterol only group of rats. Western blot did not show a difference
among groups in protein expression for endothelial nitric oxide synthase and
neuronal nitric oxide synthase in penile tissue but caveolin-1 and bFGF
protein expression was significantly higher in groups 1 and 2 than in the
cholesterol only and control groups. CONCLUSIONS:
Rats developed erectile dysfunction after being fed a 1% cholesterol diet
for 4 months. Although serum cholesterol levels were similar in the
cholesterol only rats and those treated with Chinese herbal medicine
mixture, erectile response was significantly better in the treated group.
The mechanism of the herbal medicine is unknown. High levels of
bFGF and caveolin-1 expression in the treated group may protect the
cavernous smooth muscle and endothelial cells from the harmful effect of
high serum cholesterol.
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